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Fomba fiarovana amino mahazatra

Fomba fiarovana amino mahazatra

1. Cbz
Benzyloxycarbonyl (Cbz) Protected Amino
Famotehana ny N-benzyloxycarbonyl (Cbz)
Reagents fampiasa matetika - CbzCl

2. Alloc
Allyloxycarbonyl (Alloc) vondrona amino voaaro

3. Trifluoroacetyl
Trifluoroacetyl voaaro vondrona amino

4. Benzyl
vondrona amino voaaro p-methoxybenzyl (PMB).
2,4-dimethoxybenzyl voaaro vondrona amino
Amino voaaro amin'ny Benzyl
Deprotection ny vondrona amino voaaro benzyl
N-Bn debenzylation amin'ny fomba chloroformate

5. Pht (phthaloyl)
Vondrona amino arovana Phthaloyl (Pht).
Deprotection ny vondrona amino voaaro phthaloyl

6. Benzenesulfonyl
Nitrobenzenesulfonyl voaaro vondrona amino
p-toluenesulfonyl (Tos) fiarovana amino

7. Trt
Trityl voaaro amino
Deprotection ny trityl-protected amino group

8. Boc
Tert-butoxycarbonyl protected amino group
Fanesorana ny N-tert-butoxycarbonyl
Oxalyl Chloride De-Boc

9. Fmoc
Wat methoxycarbonyl protected amino group
Reagents fampiasa matetika - Fmoc-Cl

10. SEM
Amino voaaro SEM

11. Ny hafa
Acetamide voaaro vondrona amino
Fihetseham-po synthesis pyrrole Clauson-Kaas (azo ampiasaina ho fomba hiarovana ny vondrona amino ity fanehoan-kevitra ity, afaka manolo ny fiarovana Boc avo roa heny, ary miorina kokoa)
Reagents fampiasa matetika - benzyl (chloromethyl) etera
Reagents fampiasa matetika - (chloromethyl) methyl etera [MOMCl]
Fiarovana karbamate


Fotoana fandefasana: Sep-07-2023